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NEW BOOK - ' The Blob Guide to Childrens Human Rights'
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Monday, January 08, 2018
Read this in the Guardian yesterday - deep stuff on the major issue of DEPRESSION
I
n
the 1970s, a truth was accidentally discovered about depression – one
that was quickly swept aside, because its implications
were too
inconvenient, and too explosive. American psychiatrists had produced a
book that would lay out, in detail, all the
symptoms of different mental
illnesses, so they could be identified and treated in the same way
across the United States. It was
called the
Diagnostic and Statistical Manual
.
In the latest edition, they laid out nine symptoms that a patient has
to show to be
diagnosed with depression – like, for example, decreased
interest in pleasure or persistent low mood. For a doctor to conclude
you
were depressed, you had to show five of these symptoms over several
weeks.
The manual was sent out to doctors across the US and they
began to use it to diagnose people. However, after a while they came
back to the authors and pointed out something that was bothering them.
If they followed this guide, they had to diagnose every
grieving person
who came to them as depressed and start giving them medical treatment.
If you lose someone, it turns out that
these symptoms will come to you
automatically. So, the doctors wanted to know, are we supposed to start
drugging all the
bereaved people in America?
The authors conferred, and they decided that there would be a special
clause added to the list of symptoms of depression. None of
this
applies, they said, if you have lost somebody you love in the past year.
In that situation, all these symptoms are natural, and
not a disorder.
It was called “the grief exception”, and it seemed to resolve the
problem.
Then, as the years and decades passed, doctors on the frontline
started to come back with another question. All over the world,
they
were being encouraged to tell patients that depression is, in fact, just
the result of a spontaneous chemical imbalance in your
brain – it is
produced by low serotonin, or a natural lack of some other chemical.
It’s not caused by your life – it’s caused by your
broken brain. Some of
the doctors began to ask how this fitted with the grief exception. If
you agree that the symptoms of
depression are a logical and
understandable response to one set of life circumstances – losing a
loved one – might they not be an
understandable response to other
situations? What about if you lose your job? What if you are stuck in a
job that you hate for the
next 40 years? What about if you are alone and
friendless?
Drug companies would fund huge numbers of studies and then only release the ones that showed success
The grief exception seemed to have blasted a hole in the claim that
the causes of depression are sealed away in your skull. It
suggested
that there are causes out here, in the world, and they needed to be
investigated and solved there. This was a debate
that mainstream
psychiatry (with some exceptions) did not want to have. So, they
responded in a simple way – by whittling away
the grief exception. With
each new edition of the manual they reduced the period of grief that you
were allowed before being
labelled mentally ill – down to a few months
and then, finally, to nothing at all. Now, if your baby dies at 10am,
your doctor can
diagnose you with a mental illness at 10.01am and start
drugging you straight away.
Dr Joanne Cacciatore
,
of Arizona State University, became a leading expert on the grief
exception after her own baby, Cheyenne,
died during childbirth. She had
seen many grieving people being told that they were mentally ill for
showing distress. She told me
this debate reveals a key problem with how
we talk about depression, anxiety and other forms of suffering: we
don’t, she said,
“consider context”. We act like human distress can be
assessed solely on a checklist that can be separated out from our lives,
and
labelled as brain diseases. If we started to take people’s actual
lives into account when we treat depression and anxiety, Joanne
explained, it would require “an entire system overhaul”. She told me
that when “you have a person with extreme human distress,
[we need to]
stop treating the symptoms. The symptoms are a messenger of a deeper
problem. Let’s get to the deeper problem.”
I was a teenager when I swallowed my first antidepressant. I was
standing in the weak English sunshine, outside a pharmacy in a
shopping
centre in London. The tablet was white and small, and as I swallowed, it
felt like a chemical kiss. That morning I had
gone to see my doctor and
I had told him – crouched, embarrassed – that pain was leaking out of
me uncontrollably, like a bad
smell, and I had felt this way for several
years. In reply, he told me a story. There is a chemical called
serotonin that makes people
feel good, he said, and some people are
naturally lacking it in their brains. You are clearly one of those
people. There are now,
thankfully, new drugs that will restore your
serotonin level to that of a normal person. Take them, and you will be
well. At last, I
understood what had been happening to me, and why.
However,
a few months into my drugging, something odd happened. The pain started
to seep through again. Before long, I felt as
bad as I had at the
start. I went back to my doctor, and he told me that I was clearly on
too low a dose. And so, 20 milligrams
became 30 milligrams; the white
pill became blue. I felt better for several months. And then the pain
came back through once
more. My dose kept being jacked up, until I was
on 80mg, where it stayed for many years, with only a few short breaks.
And still
the pain broke back through.
I started to research my book,
Lost Connections: Uncovering The Real Causes of Depression – and the Unexpected Solutions
,
because I was puzzled by two mysteries. Why was I still depressed when I
was doing everything I had been told to do? I had
identified the low
serotonin in my brain, and I was boosting my serotonin levels – yet I
still felt awful. But there was a deeper
mystery still. Why were so many
other people across the western world feeling like me? Around one in
five US adults are taking at
least one drug for a psychiatric problem.
In Britain, antidepressant prescriptions have doubled in a decade, to
the point where now
one in 11 of us drug ourselves to deal with these
feelings. What has been causing depression and its twin, anxiety, to
spiral in this
way? I began to ask myself: could it really be that in
our separate heads, all of us had brain chemistries that were
spontaneously
malfunctioning at the same time?
To find the answers, I ended up going on a 40,000-mile journey across
the world and back. I talked to the leading social scientists
investigating these questions, and to people who have been overcoming
depression in unexpected ways – from an Amish village
in Indiana, to a
Brazilian city that banned advertising and a laboratory in Baltimore
conducting a startling wave of experiments.
From these people, I learned
the best scientific evidence about what really causes depression and
anxiety. They taught me that it
is not what we have been told it is up
to now. I found there is evidence that seven specific factors in the way
we are living today are
causing depression and anxiety to rise –
alongside two real biological factors (such as your genes) that can
combine with these
forces to make it worse.
Once
I learned this, I was able to see that a very different set of
solutions to my depression – and to our depression – had been
waiting
for me all along.
To understand this different way of thinking, though, I had to first
investigate the old story, the one that had given me so much relief
at
first. Professor Irving Kirsch at Harvard University is the Sherlock
Holmes of chemical antidepressants – the man who has
scrutinised the
evidence about giving drugs to depressed and anxious people most closely
in the world. In the 1990s, he
prescribed chemical antidepressants to
his patients with confidence. He knew the published scientific evidence,
and it was clear: it
showed that 70% of people who took them got
significantly better. He began to investigate this further, and put in a
freedom of
information request to get the data that the drug companies
had been privately gathering into these drugs. He was confident that
he
would find all sorts of other positive effects – but then he bumped into
something peculiar.
We all know that when you take selfies, you take 30 pictures, throw
away the 29 where you look bleary-eyed or double-chinned,
and pick out
the best one to be your Tinder profile picture. It turned out that the
drug companies – who fund almost all the research
into these drugs –
were taking this approach to studying chemical antidepressants. They
would fund huge numbers of studies,
throw away all the ones that
suggested the drugs had very limited effects, and then only release the
ones that showed success. To
give one example: in one trial, the drug
was given to 245 patients, but the drug company published the results
for only 27 of them.
Those 27 patients happened to be the ones the drug
seemed to work for. Suddenly, Professor Kirsch realised that the 70%
figure
couldn’t be right.
It
turns out that between 65 and 80% of people on antidepressants are
depressed again within a year. I had thought that I was
freakish for
remaining depressed while on these drugs. In fact, Kirsch explained to
me in Massachusetts, I was totally typical.
These drugs are having a
positive effect for some people – but they clearly can’t be the main
solution for the majority of us,
because we’re still depressed even when
we take them. At the moment, we offer depressed people a menu with only
one option
on it. I certainly don’t want to take anything off the menu –
but I realised, as I spent time with him, that we would have to expand
the menu.
This led Professor Kirsch to ask a more basic question, one he was
surprised to be asking. How do we know depression is even
caused by low
serotonin at all? When he began to dig, it turned out that the evidence
was strikingly shaky. Professor Andrew Scull
of Princeton, writing in
the
Lancet
, explained that attributing depression to
spontaneously low serotonin is “deeply misleading and
unscientific”. Dr
David Healy told me: “There was never any basis for it, ever. It was
just marketing copy.”
I didn’t want to hear this. Once you settle into a story about your
pain, you are extremely reluctant to challenge it. It was like a
leash I
had put on my distress to keep it under some control. I feared that if I
messed with the story I had lived with for so long, the
pain would run
wild, like an unchained animal. Yet the scientific evidence was showing
me something clear, and I couldn’t ignore it.
So, what is really going on? When I interviewed social scientists all
over the world – from São Paulo to Sydney, from Los Angeles
to London –
I started to see an unexpected picture emerge. We all know that every
human being has basic physical needs: for
food, for water, for shelter,
for clean air. It turns out that, in the same way, all humans have
certain basic psychological needs. We
need to feel we belong. We need to
feel valued. We need to feel we’re good at something. We need to feel
we have a secure
future. And there is growing evidence that our culture
isn’t meeting those psychological needs for many – perhaps most –
people. I
kept learning that, in very different ways, we have become
disconnected from things we really need, and this deep disconnection is
driving this epidemic of depression and anxiety all around us.
Let’s look at one of those causes, and one of the solutions we can
begin to see if we understand it differently. There is strong
evidence
that human beings need to feel their lives are meaningful – that they
are doing something with purpose that makes a
difference. It’s a natural
psychological need. But between 2011 and 2012, the polling company
Gallup conducted the most detailed
study ever carried out of how people
feel about the thing we spend most of our waking lives doing – our paid
work. They found that
13% of people say they are “engaged” in their work
– they find it meaningful and look forward to it. Some 63% say they are
“not
engaged”, which is defined as “sleepwalking through their
workday”. And 24% are “actively disengaged”: they hate it.
Antidepressant prescriptions have doubled over the last decade. Photograph: Anthony Devlin/PA
Most of the depressed and anxious people I know, I realised, are in
the 87% who don’t like their work. I started to dig around to see
if
there is any evidence that this might be related to depression. It
turned out that a breakthrough had been made in answering this
question
in the 1970s, by an Australian scientist called Michael Marmot. He
wanted to investigate what causes stress in the
workplace and believed
he’d found the perfect lab in which to discover the answer: the British
civil service, based in Whitehall. This
small army of bureaucrats was
divided into 19 different layers, from the permanent secretary at the
top, down to the typists. What
he wanted to know, at first, was: who’s
more likely to have a stress-related heart attack – the big boss at the
top, or somebody
below him?
Everybody
told him: you’re wasting your time. Obviously, the boss is going to be
more stressed because he’s got more
responsibility. But when Marmot
published his results, he revealed the truth to be the exact opposite.
The lower an employee
ranked in the hierarchy, the higher their stress
levels and likelihood of having a heart attack. Now he wanted to know:
why?
And that’s when, after two more years studying civil servants, he
discovered the biggest factor. It turns out if you have no control
over
your work, you are far more likely to become stressed – and, crucially,
depressed. Humans have an innate need to feel that
what we are doing,
day-to-day, is meaningful. When you are controlled, you can’t create
meaning out of your work.
Suddenly, the depression of many of my friends, even those in fancy
jobs – who spend most of their waking hours feeling
controlled
and unappreciated – started to look not like a problem with their
brains, but a problem with their environments. There
are, I discovered,
many causes of depression like this. However, my journey was not simply
about finding the reasons why we feel
so bad. The core was about finding
out how we can feel better – how we can find real and lasting
antidepressants that work for
most of us, beyond only the packs of pills
we have been offered as often the sole item on the menu for the
depressed and anxious.
I kept thinking about what Dr Cacciatore had
taught me – we have to deal with the deeper problems that are causing
all this
distress.
I found the beginnings of an answer to the epidemic of meaningless
work – in Baltimore. Meredith Mitchell used to wake up every
morning
with her heart racing with anxiety. She dreaded her office job. So she
took a bold step – one that lots of people thought
was crazy. Her
husband, Josh, and their friends had worked for years in a bike store,
where they were ordered around and
constantly felt insecure, Most of
them were depressed. One day, they decided to set up their own bike
store, but they wanted to
run it differently. Instead of having one guy
at the top giving orders, they would run it as a democratic
co-operative. This meant they
would make decisions collectively, they
would share out the best and worst jobs and they would all, together, be
the boss. It would
be like a busy democratic tribe. When I went to
their store –
Baltimore Bicycle Works
– the staff explained how, in this different
environment, their persistent depression and anxiety had largely lifted.
It’s
not that their individual tasks had changed much. They fixed bikes
before; they fix bikes now. But they had dealt with the unmet
psychological needs that were making them feel so bad – by giving
themselves autonomy and control over their work. Josh had
seen for
himself that depressions are very often, as he put it, “rational
reactions to the situation, not some kind of biological break”.
He told
me there is no need to run businesses anywhere in the old humiliating,
depressing way – we could move together, as a
culture, to workers
controlling their own workplaces.
With each of the nine causes of depression and anxiety I learned
about, I kept being taught startling facts and arguments like this
that
forced me to think differently. Professor John Cacioppo of Chicago
University taught me that being acutely lonely is as
stressful as being
punched in the face by a stranger – and massively increases your risk of
depression. Dr Vincent Felitti in San
Diego showed me that surviving
severe childhood trauma makes you 3,100% more likely to attempt suicide
as an adult. Professor
Michael Chandler in Vancouver explained to me
that if a community feels it has no control over the big decisions
affecting it, the
suicide rate will shoot up.
This new evidence forces us to seek out a very different kind of
solution to our despair crisis. One person in particular helped me to
unlock how to think about this. In the early days of the 21st century, a
South African psychiatrist named Derek Summerfeld went to
Cambodia, at a
time when antidepressants were first being introduced there. He began
to explain the concept to the doctors he
met. They listened patiently
and then told him they didn’t need these new antidepressants, because
they already had anti-
depressants that work. He assumed they were
talking about some kind of herbal remedy.
He asked them to explain, and they told him about a rice farmer they
knew whose left leg was blown off by a landmine. He was
fitted with a
new limb, but he felt constantly anxious about the future, and was
filled with despair. The doctors sat with him, and
talked through his
troubles. They realised that even with his new artificial limb, his old
job—working in the rice paddies—was
leaving him constantly stressed and
in physical pain, and that was making him want to just stop living. So
they had an idea. They
believed that if he became a dairy farmer, he
could live differently. So they bought him a cow. In the months and
years that
followed, his life changed. His depression—which had been
profound—went away. “You see, doctor,” they told him, the cow was
an
“antidepressant”.
To
them, finding an antidepressant didn’t mean finding a way to change
your brain chemistry. It meant finding a way to solve the
problem that
was causing the depression in the first place. We can do the same. Some
of these solutions are things we can do as
individuals, in our private
lives. Some require bigger social shifts, which we can only achieve
together, as citizens. But all of them
require us to change our
understanding of what depression and anxiety really are.
This is radical, but it is not, I discovered, a maverick position. In its official statement for
World Health Day in 2017
,
the United
Nations reviewed the best evidence and concluded that “the
dominant biomedical narrative of depression” is based on “biased and
selective use of research outcomes” that “must be abandoned”. We need to
move from “focusing on ‘chemical imbalances’”, they
said, to focusing
more on “power imbalances”.
After I learned all this, and what it means for us all, I started to
long for the power to go back in time and speak to my teenage self
on
the day he was told a story about his depression that was going to send
him off in the wrong direction for so many years. I
wanted to tell him:
“This pain you are feeling is not a pathology. It’s not crazy. It is a
signal that your natural psychological needs
are not being met. It is a
form of grief – for yourself, and for the culture you live in going so
wrong. I know how much it hurts. I know
how deeply it cuts you. But you
need to listen to this signal. We all need to listen to the people
around us sending out this signal. It
is telling you what is going
wrong. It is telling you that you need to be connected in so many deep
and stirring ways that you aren’t
yet – but you can be, one day.”
If you are depressed and anxious, you are not a machine with
malfunctioning parts. You are a human being with unmet needs. The
only
real way out of our epidemic of despair is for all of us, together, to
begin to meet those human needs – for deep connection, to
the things
that really matter in life.
•
This is an edited extract from
Lost Connections: Uncovering the Real Causes of Depression – and the Unexpected Solutions
by
Johann Hari, published by Bloomsbury on 11 January (£16.99). To order a copy for £14.44 go to
guardianbookshop.com
or call
0330 333 6846. Free UK p&p over £10, online orders only.
Phone orders min p&p of £1.99. It will be available in audio at
audible.co.uk
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